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Home Community, Community Service/Volunteer, Health & Wellness, HIV/AIDS, Living, Medical, POZ Community, WeedThe UW AIDS Clinical Trials Unit Seeks Paid Volunteers For Cannabis Study

The UW AIDS Clinical Trials Unit Seeks Paid Volunteers For Cannabis Study

June 12, 2017• bySeattle Gay Scene

CannabisUWAIDSClinical

Impact of Cannabis on Inflammation and Viral Persistence in Treated HIV

The UW AIDS Clinical Trials Unit is looking for HIV-negative women and men (including transgender women & men), as well as HIV-positive women and men (again including transgender women & men) on HIV meds with an undetectable viral load for 2 years. By volunteering for this paid study, such individuals will help us to determine if cannabis use impacts inflammation in the body, abnormalities or dysfunction in the rectum or colon, and the size of the HIV reservoir, as well as to compare the gut microbiomes of HIV-negative and HIV-positive people.

Despite being undetectable, people living with HIV have ongoing inflammation, which is the body’s reaction to infection, a state where some of the immune cells remain constantly activated. Additionally, HIV damages the lining of the intestines soon after infection. This damage also leads to chronic inflammation, which can allow chemical messengers and bacteria in the gut to migrate through the wall of the intestines and get into the blood.

HIV thus sets up a vicious cycle of mucosal damage in the gut, chronic inflammation, and overall immunological dysfunction. Cannabis and its derivatives are commonly used to treat gastrointestinal ailments in HIV, including promoting appetite and decreasing nausea. Cannabis use also promotes mucosal health and cannabis derivatives (cannabinoids) show robust anti-inflammatory activity in immune cells. However, clinical investigations of the impact of cannabis on the microbiome have not been conducted.

We know the important role that the microbiome plays in health and that it changes in the context of HIV. For these reasons, it is important to investigate the impact cannabis may have on the microbiome as well as on HIV. Understanding the mechanisms by which cannabis affects inflammation and/or HIV reservoirs may help develop new interventions to improve health in people living with HIV.

Length of Study: approximately 2-4 weeks
Schedule of Study Appointments: one screening visit, followed by one procedure visit
Medications administered during study: Optional sedative during procedure visit
Study Procedures: Blood draws, self-collected rectal swabs and stool sample, and flexible sigmoidoscopy with colonic sponge sampling and biopsies
Reimbursement: Participants will receive compensation after completing all study procedures

Participant Eligibility

FOR HIV-NEGATIVE WOMEN & MEN (INCLUDING TRANSGENDER WOMEN & MEN):

  • You are 21-70 years old
  • You sometimes don’t use condoms with your sex partners or have a partner living with HIV
  • No cannabis requirement—you can use any amount per week, or not use it at all.
  • No other illicit drug use in the past 12 months

FOR HIV-POSITIVE WOMEN & MEN (INCLUDING TRANSGENDER WOMEN & MEN):

  • You are 21-70 years old
  • You are on HIV meds with an undetectable viral load for at least 2 years
  • T-cell count is above 200
  • Current use of cannabis 3 times or more per week for at least 6 months (with no other illicit drug use) — OR — have not used cannabis or any other illicit drug use in the past 12 months

FOR BOTH GROUPS:

  • No heart disease, hep C, chronic inflammatory bowel disease, autoimmune disorders, uncontrolled asthma or diabetes requiring insulin
  • No chronic opioid use
  • Not pregnant or breast feeding
  • No antibiotics in past 3 months
  • Able and willing to self–administer Fleet enemas, collect rectal swabs and stool sample at home

CannabisStudy

Contact

Eric Helgeson, RN
(206) 744-8883

Additional Study Details

Full Study Title
Impact of Cannabis on Inflammation and Viral Persistence in Treated HIV

Study ID: 49632
ClinicalTrials.gov Link:
Start Date: 08/12/2016
End Date: 08/12/2017

Investigator(s)
Ann C. Collier, MD

Accepts Healthy Volunteers?
Yes

Study Site(s)

UW AIDS Clinical Trials Unit

325 9th Avenue 2nd Floor of the West Clinic, Desk B
Seattle, Washington 98104

(Visited 2 times, 1 visits today)

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